Table 2.

Evaluation of positive and negative predictive values for AFP, LTBP2 and OPN when comparing the performance of the markers in cohort 1 (Korea) for the early detection/diagnosis of HCC.

Parameter	AFP	95% CI	LTBP2 or OPN	95% CI	LTBP2 or OPN (for patients with AFP < 20 ng/mL)	95% CI
Sensitivity	24%	8% – 47%	90%	68% – 98%	95%	75% – 99%
Specificity	81%	71% – 88%	72%	63% – 81%	90%	82% – 96%
PLR	1.24	0.52 – 2.97	3.27	2.30 – 4.65	9.97	5.12 – 19.43
NLR	0.94	0.73 – 1.22	0.14	0.04 – 0.52	0.06	0.01 – 0.37
PPV	21%	8% – 44%	40%	26% – 56%	70%	50% – 86%
NPV	82%	73% – 90%	97%	90% – 99%	98%	93% – 99%

PLR = positive likelihood ration, NLR = negative likelihood ratio, PPV = positive predictive value, NPV = negative predictive value.