Fig. 6.

Differential transcription of genes involved in the modification of HS chains. a, b Relative transcript abundance of mRNAs for enzymes involved in the modification of HS chains. Relative abundance for healthy tissues (gray bars) and tumors (black bars) are plotted on a log scale for each gene assayed and the spreads represent standard deviations. Genes that display significant differences in their transcription levels are highlighted. a Non-metastatic CRCs. 1: N-deacetylase/N-sulfotransferase 1 (p < 0.008); 2: N-deacetylase/N-sulfotransferase 2 (p = 0.008); 3: 6-O-sulfotransferase 1 (p = 0.007); 4: 3-O-sulfotransferase 3B (p = 0.04); 5: 3-O-sulfotransferase 5 (p = 0.009) b Metastatic CRCs. c Relative expression ratio of genes that show statistically significant differences in expression in non-metastatic (●) or metastatic (■) CRCs. Values on the Y axis are represented on a logarithmic scale