Fig. 7.

Differential transcription of genes involved in the modification of CS/DS chains. a, b Relative transcript abundance of mRNAs for enzymes involved in the modification of CS/DS chains. Relative abundance for healthy tissues (gray bars) and tumors (black bars) are plotted on a log scale for each gene assayed and the spreads represent standard deviations. Genes that display significant differences in their transcription levels are highlighted. a Non-metastatic CRCs. 1: chondroitin 4 sulfotransferase 11 (p = 0.008); 2: chondroitin 4 sulfotransferase 12 (p = 0.011); 3: N-acetylgalactosamine 4 sulfotransferase 14 (p = 0.012); 4: dermatan sulfate epimerase (p = 0.017); 5: uronyl-2-sulfotransferase (p = 0.012). b Metastatic CRCs. 1: chondroitin 4 sulfotransferase 11 (p = 0.02); 2: chondroitin 4 sulfotransferase 12 (p = 0.025); 3: N-acetylgalactosamine 4 sulfotransferase 14 (p = 0.035); 4: dermatan sulfate epimerase (p = 0.046); 5: uronyl-2-sulfotransferase (p = 0.05). c Relative expression ratio of genes that show statistically significant differences in expression in non-metastatic (●) or metastatic (■) CRCs. Values on the Y axis are represented on a logarithmic scale