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. 2015 Oct 20;15:742. doi: 10.1186/s12885-015-1724-9

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© Fernández-Vega et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Immunolocalization of heparanases. a, b Immunostaining of heparanase. a Normal mucosa showing intense cell labeling; b Non-metastatic CRC from the same patient showing a decrease in immunostaining. c, d Immunostaining of heparanase 2. Normal mucosa (c) and tumor (d) samples from the same patient displaying similar immunoreactivity. Magnification 400X