Table 1. Characterization of HCMV neutralizing antibodies.

Binding affinities of recombinant Pentamer and gH/gL/gO to human neutralizing antibodies as measured by SPR.

Sample	Site	Antibody	ka (1E+5/Ms)	kd (1E-4/s)	KD (nM)	Rmax (RU)	Chi2 (RU2)	Ligand Level (RU)
Pentamer	1	15D8	6.3	6.0	0.95	63.3	0.26	58.6
	2	10F7	7.1	7.5	1.05	23.7	0.114	46.8
	3	4N10	7.9	0.6	0.08	23.2	0.109	12.2
	4	10P3	7.4	0.7	0.09	54	0.333	51.8
	5	2C12	4.2	0.4	0.11	35.2	0.0727	52
	6	7I13	7.9	0.5	0.06	88.6	0.704	48.2
	7	8I21	3.4	0.7	0.19	33.26	0.0817	37.5
	gH-1	3G16	4.3	0.9	0.21	26.9	0.0706	53.2
	gH-2	13H11	3.1	1.9	0.62	11.4	0.0465	72.6
	gH-3	MSL-109*	9.2	0.7	0.08	104.1	0.0254	48
gH/gL/gO	gH-1	3G16	9.6	0.8	0.08	43.9	0.261	55.8
	gH-2	13H11	4.8	1.1	0.24	19.6	0.099	84.5
	gH-3	MSL-109*	10.4	0.7	0.06	90.6	0.0294	45

*MSL-109 values previously reported in Ciferri et al., 2015.