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. Author manuscript; available in PMC: 2016 Oct 20.
Published in final edited form as: Eur J Med Chem. 2015 Aug 29;103:226–237. doi: 10.1016/j.ejmech.2015.08.047

Figure 6.

Figure 6

(A) Evaluation of compound 5 in a [3H]-RTX TRPV1 displacement assay. Effects of 1 and 5 at the concentration of 10 μM on the specific binding of [3H]-RTX to the vanilloid site of TRPV1 receptor from rats spinal cord membranes. Results are expressed as mean ± S.E.M from 3 independent experiments, analyzed by one way analysis of variance (ANOVA), followed by Dunnett's multiple comparison test (***p<0.05 and ****p<0.001). (B and C) Evaluation of 5 for TRPV1 activity in MDA-MB-231 breast cancer cells. (B) Effect of 1 (80 μM) on MDA-MB-231 [Ca2+]i. (C) Effect of 5 (20 μM) on MDA-MB-231 [Ca2+]i.

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