Table 1.
compound | GI50
in vitro values (μM)a |
|||||
---|---|---|---|---|---|---|
A549 | SKMEL-28 | MCF-7 | U373 | Hs683 | Mean + SEM | |
1 | 90 | 65 | 75 | >99 | 95 | > 85 ± 6 |
5 | 21 | 27 | 7 | 22 | 24 | 20 ± 3 |
6 | 25 | 29 | 30 | 37 | 29 | 30 ± 2 |
7 | 26 | 37 | 27 | 37 | 28 | 31 ± 2 |
8 | 29 | 41 | 32 | 40 | 29 | 34 ± 3 |
9 | 28 | 39 | 27 | 39 | 31 | 33 ± 3 |
10 | 29 | 25 | 31 | 27 | 12 | 25 ± 3 |
11 | 27 | 42 | 31 | 36 | 28 | 33 ± 3 |
12 | 24 | 28 | 20 | 25 | 22 | 24 ± 1 |
13 | 30 | 36 | 30 | 35 | 33 | 33 ± 1 |
Average concentration required to reduce the viability of cells by 50% after a 72 h treatment relative to a control, each experiment performed in sextuplicates, as determined by MTT assay.