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. Author manuscript; available in PMC: 2016 Oct 20.
Published in final edited form as: Eur J Med Chem. 2015 Aug 29;103:226–237. doi: 10.1016/j.ejmech.2015.08.047

Table 1.

In Vitro growth inhibitory effects of the C12-Wittig derivatives of 1

compound GI50 in vitro values (μM)a
A549 SKMEL-28 MCF-7 U373 Hs683 Mean + SEM
1 90 65 75 >99 95 > 85 ± 6
5 21 27 7 22 24 20 ± 3
6 25 29 30 37 29 30 ± 2
7 26 37 27 37 28 31 ± 2
8 29 41 32 40 29 34 ± 3
9 28 39 27 39 31 33 ± 3
10 29 25 31 27 12 25 ± 3
11 27 42 31 36 28 33 ± 3
12 24 28 20 25 22 24 ± 1
13 30 36 30 35 33 33 ± 1
a

Average concentration required to reduce the viability of cells by 50% after a 72 h treatment relative to a control, each experiment performed in sextuplicates, as determined by MTT assay.