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Antiproliferative effects of 5 against MDR cells
| GI50
in vitro values (μM)a |
||
|---|---|---|
| MES-SA | MES-SA/Dx5 | |
|
|
||
| Paclitaxel | 0.007 | 10 |
| Vinblastine | 0.006 | 5 |
| 5 | 40 | 45 |
Concentration required to reduce the viability of cells by 50% after a 48 h treatment with the indicated compounds relative to a DMSO control from two independent experiments, each performed in 4 replicates, as determined by the MTT assay.
