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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Biomaterials. 2015 Sep 2;72:138–151. doi: 10.1016/j.biomaterials.2015.08.050

Figure 6. FGF-2/IL-10 coacervate enhances long-term vascular stromal cell density.

Figure 6

Vascular stromal cell density at the infarct and peri-infarct border zone was revealed by immunohistochemical detection of vascular smooth muscle cells (VSMC, defined as perivascular/peri-CD31 αSMA+ cells; representative images shown in Figure 5A) at 6 weeks post-infarction. (A) Quantitative analyses of perivascular aSMA+ VSMC density within the infarct area revealed that Coa-F/I-500/500 had significantly higher VSMC density than the saline control, Free-F/I-500/500, and Coa-F-500 (*p≤0.05; N=4 per group). (B) Coa-F/I-500/100 and Coa-F/I-500/500 had marginally higher VSMC density than the saline control, Free-F/I-500/500, and Coa-F-500 within the peri-infarct area (all p>0.05; N=4 per group). Error bars indicate means ± SD. Statistical differences between groups were analyzed by one-way ANOVA with Bonferroni post-hoc analysis.