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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Gastroenterology. 2015 Apr 8;149(1):56–66.e5. doi: 10.1053/j.gastro.2015.04.003

Figure 2.

Figure 2

(A,B) Representative images showing depletion of the ICC network in the gastric smooth muscle in a CUNV patient (A) compared to control (B). The red signal is Kit immunoreactivity marking ICC; the blue signal is 4’,6’-diamidino-2-phenylindone counterstain marking cellular nuclei. (C,D) Electron microscopy images showing mild ultrastructural abnormalities in a CUNV patient (C) compared to control (D). Labeled structural components: thick basal lamina (small astericks), nerve endings (NE), smooth muscle cells (SMC), lamellar body (LB), ICC-SMC contact (arrows), and peg-and-socket junction (large astericks).