Table 2.

Endothelial products in coagulation

Protein/Receptor	Function
PAR	Induces release of nitric oxide and prostacyclin I2, activation of Weibel-Palade bodies, and expression of TF
TF	Triggers the production of thrombin through activation of fX when in complex with fVIIa
fVIII/fVIIIa	Amplifies the production of thrombin when in complex with fIXa
VWF	Tethers platelets to collagen via glycoprotein VI on platelets
	Stabilizes fVIII in plasma
TFPI	Inhibits the activity of the TF/fVIIa complex and fXa
Thrombomodulin	Eliminates the activity of thrombin when in complex
	Induces the activation of the protein C pathway
EPCR	Catalyzes conversion of Protein C to activated Protein C
t-PA	Triggers fibrinolysis by converting plasminogen to plasmin

Abbreviations: EPCR endothelial protein C receptor, f factor, PAR protease-activated receptor, TF tissue factor, TFPI tissue factor pathway inhibitor, t-PA tissue-type plasminogen activator, VWF von Willebrand factor