Table 2.

Cohort Groups and Study Methods

Cohort name	Cohort description	Covariates included in analysis	Number of statin nonusers	Number of statin users
Primary analysis
Propensity score-matched cohort	Pairs of statin users and nonusers were matched based on propensity score	None, since cohort groups were matched with no imbalance	3351	3351
Secondary and sensitivity analyses
Healthy cohort	Healthy individuals who met the inclusion and exclusion criteria	Propensity score	21,988	3982
High-intensity statin-user cohort	A subset of the “healthy cohort,” restricting statin users to those who used high-intensity statins at any point of their follow-up	Propensity score	21,988	1155
Two-year statin-user cohort	A subset of the “healthy cohort,” after excluding statin users who used statins for less than 2 years	Propensity score	21,988	3308
Four-year statin-user cohort	A subset of the “healthy cohort,” after excluding statin users who used statins for less than 4 years	Propensity score	21,988	2933
Overweight/obesity incident cohort	A subset of the “healthy cohort,” after excluding patients who were diagnosed in the baseline period with overweight/obesity	Propensity score	20,176	3415
High-intensity statin users among statin users only	All statin users only in the “healthy cohort,” comparing outcomes between high-intensity statin users and moderate/low-intensity statin users	Propensity score	None included	3982