Table 7.
Secondary and Sensitivity Analyses of Outcomes in Statin Users and Nonusers
| Outcome | Statin nonusers | Statin users | Adjusted odds ratioa | 95 % CI | p value | |
|---|---|---|---|---|---|---|
| Healthy cohort (21,988 nonusers and 3 982 statin users) | ||||||
| Diabetes mellitus | 2421 (11.0) | 1293 (32.5) | 2.11 | 1.92 | 2.32 | <0.001 |
| Diabetes mellitus with complications | 213 (1.0) | 214 (5.4) | 2.78 | 2.18 | 3.53 | <0.001 |
| Overweight/obese | 8608 (39.2) | 1851 (46.5) | 1.22 | 1.13 | 1.33 | <0.001 |
| High-intensity statin-users cohort (21,988 nonusers and 1 155 statin users) | ||||||
| Diabetes mellitus | 2421 (11.0) | 454 (39.3) | 2.55 | 2.21 | 2.94 | <0.001 |
| Diabetes mellitus with complications | 213 (1.0) | 95 (8.2) | 3.68 | 2.70 | 5.00 | <0.001 |
| Overweight/obese | 8608 (39.2) | 632 (54.7) | 1.58 | 1.34 | 1.80 | <0.001 |
| Two-year statin-user cohort (21,988 nonusers and 3 308 statin users) | ||||||
| Diabetes mellitus | 2421 (11.0) | 1120 (33.9) | 2.16 | 1.95 | 2.40 | <0.001 |
| Diabetes mellitus with complications | 213 (1.0) | 184 (5.6) | 2.60 | 2.01 | 3.35 | <0.001 |
| Overweight/obese | 8608 (39.2) | 1552 (46.9) | 1.24 | 1.14 | 1.35 | <0.001 |
| Four-year statin-user cohort (21,988 nonusers and 2 933 statin users) | ||||||
| Diabetes mellitus | 2421 (11.0) | 1028 (35.0) | 2.24 | 2.01 | 2.49 | <0.001 |
| Diabetes mellitus with complications | 213 (1.0) | 169 (5.8) | 2.71 | 2.08 | 3.52 | <0.001 |
| Overweight/obese | 8608 (39.2) | 1373 (46.8) | 1.22 | 1.11 | 1.33 | <0.001 |
| Overweight/obesity incident cohort (20,176 nonusers and 3 415 statin users) | ||||||
| Diabetes mellitus | 2045 (10.1) | 1060 (31.0) | 2.14 | 1.92 | 2.37 | <0.001 |
| Diabetes mellitus with complications | 169 (0.8) | 159 (4.7) | 2.87 | 2.17 | 3.79 | <0.001 |
| Overweight/obese | 7078 (35.1) | 1371 (40.1) | 1.26 | 1.16 | 1.38 | < 0.001 |
aAdjusted for propensity score