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. 2015 Oct 15;29(20):2140–2152. doi: 10.1101/gad.267997.115

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© 2015 Dai et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Sensitivities of cell lines to navitoclax and A1210477 correlate with BAK binding status. (A,B) After the cell lines were treated with navitoclax (A) or A1210477 (B), the percentages of Annexin V-positive cells were assessed by flow cytometry. Graphs show the average of three independent experiments. Symbols and line colors represent different BAK binding statuses. (Red) No binding; (blue) BAK bound to BCLX_L only; (yellow) BAK bound to MCL1 only; (purple) unknown binding partner; (green) BAK bound to multiple partners. (C,D) Concentrations of navitoclax (C) or A1210477 (D) required to induce apoptosis in 50% of cells (IC₅₀) grouped according to BAK binding status as determined in Figure 3 and Supplemental Figure S5. Symbols for each cell line correspond to the key between A and B. Heavy horizontal lines represent the mean, and error bars indicate the SD of the indicated groups of lines.