Table II.
Incidence Rates and Hazard Ratios (HRs) of Venous Thromboembolism in Relation to Factor XI, ARIC, 1993–2011, CHS 1992–2001
| Quintile of Factor XI (Ag %) | ||||||||
|---|---|---|---|---|---|---|---|---|
| 8.0–92.2 | 92.2–105.1 | 105.1–117.3 | 117.3–133.4 | 133.4–400.0 | p-trend | Per 1-SD increment in FXI* |
p-value | |
| Pooled | ||||||||
| Total VTE | ||||||||
| N of VTEs | 101 | 113 | 121 | 129 | 142 | |||
| Person years | 42,040 | 44,224 | 44,127 | 43,713 | 41,656 | |||
| Incidence rate (per 103 py) | 2.4 | 2.6 | 2.7 | 3.0 | 3.4 | |||
| Model 1 HR (95% CI)† | 1 (Ref.) | 1.09 (0.83, 1.43) | 1.19 (0.91, 1.55) | 1.31 (1.00, 1.70) | 1.51 (1.16, 1.97) | <0.001 | ||
| Model 2 HR (95% CI)‡ | 1 (Ref.) | 1.09 (0.83, 1.43) | 1.13 (0.86, 1.47) | 1.24 (0.95, 1.62) | 1.40 (1.07, 1.82) | 0.007 | 1.10 (1.02, 1.19) | 0.02 |
| Unprovoked VTE | ||||||||
| N of VTEs | 40 | 45 | 42 | 45 | 57 | |||
| Model 1 HR (95% CI)† | 1 (Ref.) | 1.11 (0.73, 1.71) | 1.06 (0.69, 1.64) | 1.19 (0.77, 1.83) | 1.60 (1.05–2.42) | 0.02 | ||
| Model 2 HR (95% CI)‡ | 1 (Ref.) | 1.11 (0.72, 1.70) | 0.99 (0.64, 1.54) | 1.10 (0.71, 1.70) | 1.49 (0.98, 2.26) | 0.06 | 1.15 (1.01, 1.30) | 0.03 |
| Provoked VTE | ||||||||
| N of VTEs | 61 | 68 | 79 | 84 | 85 | |||
| Model 1 HR (95% CI)† | 1 (Ref.) | 1.08 (0.77, 1.53) | 1.27 (0.91, 1.78) | 1.39 (0.99, 1.94) | 1.48 (1.05, 2.07) | 0.009 | ||
| Model 2 HR (95% CI)‡ | 1 (Ref.) | 1.08 (0.76, 1.53) | 1.21 (0.87, 1.70) | 1.33 (0.95, 1.86) | 1.35 (0.96, 1.90) | 0.05 | 1.07 (0.97, 1.19) | 0.19 |
| PE | ||||||||
| N of PEs | 43 | 48 | 64 | 73 | 72 | |||
| Model 1 HR (95% CI)† | 1 (Ref.) | 1.07 (0.71, 1.61) | 1.42 (0.96, 2.10) | 1.66 (1.13, 2.43) | 1.72 (1.17, 2.53) | <0.001 | ||
| Model 2 HR (95% CI)‡ | 1 (Ref.) | 1.06 (0.70, 1.61) | 1.32 (0.90, 1.96) | 1.54 (1.05, 2.27) | 1.58 (1.07, 2.33) | 0.006 | 1.17 (1.05, 1.30) | 0.003 |
| DVT | ||||||||
| N of DVTs | 58 | 65 | 57 | 56 | 70 | |||
| Model 1 HR (95% CI)† | 1 (Ref.) | 1.12 (0.79, 1.60) | 1.01 (0.70, 1.46) | 1.05 (0.72, 1.52) | 1.38 (0.96, 1.97) | 0.11 | ||
| Model 2 HR (95% CI)‡ | 1 (Ref.) | 1.12 (0.78, 1.60) | 0.97 (0.67, 1.40) | 1.00 (0.69, 1.46) | 1.27 (0.88, 1.82) | 0.28 | 1.03 (0.91, 1.16) | 0.65 |
| Total VTE, African Americans | ||||||||
| N of VTEs | 29 | 37 | 29 | 41 | 54 | |||
| Model 1 HR (95% CI)† | 1 (Ref.) | 1.15 (0.71, 1.88) | 0.91 (0.54, 1.53) | 1.27 (0.79, 2.06) | 1.72 (1.08, 2.73) | 0.01 | ||
| Model 2 HR (95% CI)‡ | 1 (Ref.) | 1.13 (0.70, 1.84) | 0.81 (0.48, 1.36) | 1.18 (0.73, 1.91) | 1.51 (0.94, 2.42) | 0.05 | 1.15 (1.01, 1.29) | 0.03 |
| Total VTE, Whites | ||||||||
| N of VTEs | 72 | 76 | 92 | 88 | 88 | |||
| Model 1 HR (95% CI)† | 1 (Ref.) | 1.07 (0.77, 1.47) | 1.32 (0.97, 1.80) | 1.33 (0.97, 1.82) | 1.42 (1.03, 1.95) | 0.01 | ||
| Model 2 HR (95% CI)‡ | 1 (Ref.) | 1.07 (0.77, 1.47) | 1.27 (0.93, 1.73) | 1.26 (0.92, 1.73) | 1.32 (0.96, 1.82) | 0.06 | 1.07 (0.97, 1.19) | 0.17 |
*
FXI standard deviation = 28.2.
†
Age, race, sex, and study adjusted, except race omitted when stratified.
‡
Adjusted further for diabetes and BMI.