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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2015 Sep 11;8(5):717–726. doi: 10.1161/CIRCGENETICS.115.001079

Table 1.

Effects of lead SNPs on circulating IL-18 levels in discovery and replication

Meta-analysis AtheroGene PRIME MONICA/KORA S1/S2/S3
SNP (coding/non coding allele) Chr Gene Beta SE P AF† Beta SE P AF† Beta SE P AF† Beta SE P AF†
rs385076 (T/C) 2 NLRC4 −0.093 0.007 2.4×10−45 35.6 −0.107 0.017 9.0×10−10 39.7 −0.098 0.032 0.002 35.4 −0.107 0.026 4.0×10−5 36.5
rs11606049 (T/C) 11 IL18 −0.089 0.007 4.6×10−35 24.5 −0.060 0.020 0.0027 26.0 −0.109 0.029 0.004 19.9 - - -
rs5744222 (A/C)* −0,085 0,007 9.2×10−32 75.1 - - - - - - - −0.110 0.030 3.0×10−4

Beta refers to the effect estimate and SE to the standard error from the linear regression model after adjustment for sex and age. For each SNP, the chromosome (Chr) and nearest gene (Gene) is shown. Discovery meta-analysis in GHS I and II, FHS and KORA F4. AtheroGene, PRIME and MONICA/KORA S1/S2/S3 were used as independent replication cohorts.

*

proxy SNP for rs11606049 with R² > 0.9 according to SNAP19. † Allele frequency (AF) of the coding allele in %.