Table 2.
Variance of circulating IL-18 levels explained by SNPs.
| Variant (Allele) | Gene | Explained variance (R²) | |||
|---|---|---|---|---|---|
| GHS I | GHS II | KORA F4 | FHS | ||
| Sample size | 2,743 | 1,073 | 1,802 | 2,940 | |
| rs385076 (T) | NLRC4 | 2.05% | 2.22% | 2.55% | 2.19% |
| rs11606049 (T) | IL18 | 1.51% | 3.32% | 1.89% | 1.03% |
| rs385076 (T) + rs11606049 (T) | NLRC4 +IL18 | 3.68% | 5.49% | 4.50% | 3.15% |
SNPs were combined by adding the allele dosages of rs385076 T and rs11606049 T for each individual resulting in a number of protective alleles between 0 and 4. The R² is the estimated percentage of explained variance for loge-transformed IL-18 by SNPs. It is calculated by substracting the explained variance of sex and age on log-transformed IL-18 from the multivariate model.