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. Author manuscript; available in PMC: 2016 Oct 1.

Published in final edited form as: Mol Cancer Res. 2015 Jun 29;13(10):1431–1440. doi: 10.1158/1541-7786.MCR-14-0569

The 4-marker immunohistochemical score for PI3K activation is positively correlated with AR staining; (A) 4-marker immunohistochemical score of PI3K activation relative to AR staining; (B) 17-gene mRNA signature of AR flux score in low (−4 to −2) and high (2 to 4) immunohistochemical score cases showing no significant differences; and (C) heatmap of tertile of immunohistochemical staining four all four marker with corresponding annotation of (top to bottom) Ki67, TUNEL, age at diagnosis, lethal outcome, Gleason score, and the 4-marker score.

The 4-marker immunohistochemical score for PI3K activation is positively correlated with AR staining; (A) 4-marker immunohistochemical score of PI3K activation relative to AR staining; (B) 17-gene mRNA signature of AR flux score in low (−4 to −2) and high (2 to 4) immunohistochemical score cases showing no significant differences; and (C) heatmap of tertile of immunohistochemical staining four all four marker with corresponding annotation of (top to bottom) Ki67, TUNEL, age at diagnosis, lethal outcome, Gleason score, and the 4-marker score.