Table 2.
The Cox regression analysis of prognostic factors in epithelial ovarian cancer
| Factors | β | Hazard ratio | 95 % confidence interval | P |
|---|---|---|---|---|
| Clinicopathological factors | ||||
| Parity | 0.009 | |||
| 0–1 | Reference | |||
| 2–3 | 0.103 | 0.668 | 0.410–1.089 | |
| >3 | 1.069 | 2.911 | 1.203–7.044 | |
| Peritoneal metastasis | 0.047 | |||
| No | Reference | |||
| Yes | 1.086 | 2.963 | 1.013–8.664 | |
| FIGO stage | 0.021 | |||
| I | Reference | |||
| II | 0.722 | 2.058 | 0.603–7.025 | |
| III | 1.150 | 3.158 | 0.730–13.658 | |
| IV | 1.470 | 4.351 | 1.611–11.746 | |
| Tumor type | <0.001 | |||
| I | Reference | |||
| II | 1.613 | 5.017 | 2.501–10.067 | |
| Residual disease | <0.001 | |||
| ≤0.5 cm | Reference | |||
| >0.5 cm | 1.553 | 4.725 | 2.418–9.233 | |
| Molecular factors | ||||
| HER2 | <0.001 | |||
| Low expression | Reference | |||
| High expression | 1.242 | 3.463 | 1.839–6.523 | |
| KRAS | <0.001 | |||
| Low expression | Reference | |||
| High expression | 1.332 | 3.787 | 1.959–7.319 | |
| BRCA1 | 0.003 | |||
| High expression | Reference | |||
| Low expression | 0.957 | 2.604 | 1.398–4.849 | |
| BRAF | 0.012 | |||
| High expression | Reference | |||
| Low expression | 1.043 | 2.838 | 1.261–6.383 | |
| EGFR | 0.036 | |||
| Low expression | Reference | |||
| High expression | 0.622 | 1.862 | 1.042–3.327 | |