Table 2.
Primary Analysisa,b | II | IV/VV | |||
---|---|---|---|---|---|
MD | M, SD | M, SD | F | p | partial eta2 |
Left Hemisphere | |||||
Frontal | 0.989 ± 0.0767 | 0.950 ± 0.0485 | 2.93 | 0.098 | 0.095 |
Temporal | 0.901 ± 0.0523 | 0.859 ± 0.0351 | 6.95 | 0.013* | 0.199 |
Parietal | 0.999 ± 0.0867 | 0.937 ± 0.0447 | 6.84 | 0.014* | 0.196 |
Occipitalc | 0.858 ± 0.0621 | 0.803 ± 0.0397 | 8.91 | 0.241 | |
Right Hemisphere | |||||
Frontal | 0.990 ± 0.0795 | 0.946 ± 0.0503 | 3.38 | 0.077 | 0.108 |
Temporal | 0.912 ± 0.0650 | 0.868 ± 0.0457 | 4.43 | 0.044* | 0.137 |
Parietalc | 1.011± 0.0841 | 0.944 ± 0.0429 | 8.46 | 0.232 | |
Occipital | 0.867 ± 0.0620 | 0.818 ± 0.0442 | 6.16 | 0.019* | 0.180 |
ADd | |||||
Left Hemisphere | |||||
Frontal | 1.13 ± 0.0814 | 1.09 ± 0.0491 | 2.67 | 0.114 | 0.087 |
Temporal | 1.07 ± 0.0566 | 1.02 ± 0.0400 | 8.03 | 0.008* | 0.223 |
Parietal | 1.13 ± 0.103 | 1.06 ± 0.0436 | 6.72 | 0.015* | 0.194 |
Occipital | 10.0 ± 0.0983 | 0.94 ± 0.0380 | 6.22 | 0.019* | 0.182 |
Right Hemisphere | |||||
Frontal | 1.13 ± 0.0835 | 1.09 ± 0.0526 | 3.47 | 0.073 | 0.110 |
Temporal | 1.09 ± 0.0762 | 1.04 ± 0.0521 | 4.81 | 0.037* | 0.147 |
Parietal | 1.15 ± 0.0101 | 1.07 ± 0.0419 | 9.21 | 0.005* | 0.248 |
Occipital | 1.01 ± 0.0835 | 0.95 ± 0.0390 | 4.96 | 0.034* | 0.151 |
RDc | |||||
Left Hemisphere | |||||
Frontal | 0.919 ± 0.0748 | 0.880 ± 0.0485 | 3.04 | 0.092 | 0.098 |
Temporal | 0.816 ± 0.0357 | 0.778 ± 0.0357 | 5.56 | 0.026* | 0.166 |
Parietal | 0.932 ± 0.0804 | 0.873 ± 0.0459 | 6.61 | 0.016* | 0.191 |
Occipital | 0.786 ± 0.0503 | 0.734 ± 0.0418 | 9.19 | 0.005* | 0.247 |
Right Hemisphere | |||||
Frontal | 0.917 ± 0.0777 | 0.875 ± 0.0495 | 3.30 | 0.080 | 0.105 |
Temporal | 0.823 ± 0.0621 | 0.785 ± 0.0450 | 3.79 | 0.062 | 0.119 |
Parietal | 0.941 ± 0.0791 | 0.880 ± 0.0442 | 7.39 | 0.011* | 0.209 |
Occipital | 0.793 ± 0.0497 | 0.751 ± 0.0475 | 5.31 | 0.029* | 0.159 |
Individuals with an ApoE4 allele were excluded from the primary analysis. II genotypes (n = 11) were compared against IV/VV genotypes (n = 19).
Diffusivity was measured in non-standard units of s/mm2 .
MD in the left occipital and right parietal lobes remained significant after applying a Sequential Bonferonni correction (See Supplement for adjusted cutoffs).
Results of the multivariate omnibus test for AD and RD did not reach statistical significance in either hemisphere.