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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Cell Rep. 2015 Oct 8;13(3):533–545. doi: 10.1016/j.celrep.2015.09.023

Figure 6. Rescue of Tfr1hrt/hrt mice with continuous iron.

Figure 6

Iron overload achieved by Fe dextran administration to mutant animals and WT littermates at P3 and an Hjv−/− hemochromatosis background provided sufficient iron to fully rescue Tfr1hrt/hrt mice.

(A) Dpyd and H-ferritin levels at 10 weeks.

(B) Proteins representative of ETC complexes at 10 weeks.

(C–H) Markers of autophagy, as indicated in the panels, at 10 weeks of age.

Data are presented as means ± SEM. Sample size (n) is indicated; n.s., not significant by one-way ANOVA. See also Figure S5.