Table 3.
Risk Score predicting Early (6-month) Distant Brain Failure
| Points | Characteristic |
|---|---|
| 1 | No previous WBRT |
| 1 | Total volume of disease <1.3cm3 |
| 1 | Primary Breast or Melanoma |
| 1 | ≥2 brain metastases |
| Points | Risk Group | 6-month DBF | HR (95% CI) and p-value | 6-month Salvage WBRT | HR (95% CI) and p-value |
|---|---|---|---|---|---|
| ≥3 points | High Risk | 54.4% | 3.04 (2.01 – 4.61), p<0.001 | 25.7% | 4.15 (2.03 – 8.48), p<0.001 |
| 2 points | Intermediate Risk | 28.8% | 1.64 (1.11 – 2.44), p=0.013 | 17.7% | 2.28 (1.08 – 4.81), p=0.03 |
| 0-1 points | Low Risk | 16.6% | Reference | 2% | Reference |
DBF = Distant Brain Failure, WBRT = Whole Brain Radiation Therapy, HR = Hazard Ratio, CI = Confidence Interval