Fig 2. Wild-type (wt, A) and muscular distrophy (mdx, B) myofiber cross-sectional area distribution plot (1300 and 1800 myofibers respectively).

WT normal distribution mean $\widehat{\mu }$ and spread $\widehat{s}$ parameters: ${\widehat{\mu }}_{\mathrm{\text{WT, untreated}}}\pm {\widehat{\sigma }}_{{\widehat{\mu }}_{\mathrm{\text{WT, untreated}}}}=2387\pm 29$ μm², ${\widehat{s}}_{\mathrm{\text{WT, untreated}}}\pm {\widehat{\sigma }}_{{\widehat{s}}_{\mathrm{\text{WT, untreated}}}}=719\pm 21$ μm², ${\widehat{\mu }}_{\mathrm{\text{WT, RAP-031}}}\pm {\widehat{\sigma }}_{{\widehat{\mu }}_{\mathrm{\text{WT, RAP-031}}}}=2597\pm 35$ μm², ${\widehat{s}}_{\mathrm{\text{WT, RAP-031}}}\pm {\widehat{\sigma }}_{{\widehat{s}}_{\mathrm{\text{WT, RAP-031}}}}=918\pm 25$ μm². MDX inverse normal distribution mean μ and shape λ parameters: ${\widehat{\mu }}_{\mathrm{\text{MDX, untreated}}}\pm {\widehat{\sigma }}_{{\widehat{\mu }}_{\mathrm{\text{MDX, untreated}}}}=1795\pm 56$ μm², ${\widehat{\lambda }}_{\mathrm{\text{MDX, untreated}}}\pm {\widehat{\sigma }}_{{\widehat{\lambda }}_{\mathrm{\text{MDX, untreated}}}}=2273\pm 114$ μm², ${\widehat{\mu }}_{\mathrm{\text{MDX, RAP-031}}}\pm {\widehat{\sigma }}_{{\widehat{\mu }}_{\mathrm{\text{MDX, RAP-031}}}}=2018\pm 58$ μm², ${\widehat{\lambda }}_{\mathrm{\text{MDX, RAP-031}}}\pm {\widehat{\sigma }}_{{\widehat{\lambda }}_{\mathrm{\text{MDX, RAP-031}}}}=2460\pm 110$ μm². In detail, the distribution of the estimated mean values ${\widehat{\mu }}_{\mathrm{\text{WT}}}$ and ${\widehat{\mu }}_{\mathrm{\text{MDX}}}$ (see S1 Table). The horizontal bars are the mean and standard error of the mean. Colors: gray dots, solid black line and gray bars, untreated; black dots, dashed black line and white bars, RAP−031. (C) Hematoxylin and eosin staining of gastrocnemius. The scale bar indicates 100 μm (40X magnification).