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. 2015 Oct 21;34:126. doi: 10.1186/s13046-015-0239-1

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© Chen et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Kaplan-Meier survival curves for NSCLC patients with different rpS6 and p-rpS6 expressions. a The survival among the whole cohort patients on the basis of t-rpS6, p-rpS6, p-rpS6/t-rpS6 showed the great significance of increased p-rpS6 and elevated p-rpS6/t-rpS6 in NSCLC (both P < 0.001) and excluded the role of t-rpS6 overexpression (P > 0.05). b Survival cures indicated the important prognostic values of the increased p-rpS6 and elevated p-rpS6/t-rpS6 in early staged NSCLC patients (both P < 0.001). c The hyperphosphorylation of rpS6 also predicted the poor prognosis of advanced staged NSCLC patients (both P < 0.05), although the significance was not as remarkable as it in I stage cases. t-rpS6: total rpS6; p-rpS6: phosphorylation of rpS6