Table 3.

Multivariate analysis for the independent risk factors for all patients (Multivariate Cox regression model with the method of forward LR)

Factors		HR	95 % CI	P
Including p-rpS6 alone
Stage	II + III + IV vs I	3.252	2.239–4.723	<0.001*
p-rpS6	P vs N	2.403	1.275–2.226	<0.001*
Including p-rpS6/rpS6 alone
Stage	II + III + IV vs I	2.377	1.631–3.465	<0.001*
p-rpS6/rpS6	≥0.67 vs < 0.67	4.311	3.154–5.894	<0.001*
Including both of p-rpS6 and p-rpS6/rpS6
Stage	II + III + IV vs I	2.377	1.631–3.465	<0.001*
p-rpS6/rpS6	≥0.67 vs < 0.67	4.311	3.154–5.894	<0.001*

HR hazard ratio; CI confidence interval; t-rpS6 total rpS6; p-rpS6 phosphorylation of rpS6; P positive expression; N negative expression

*: P < 0.05