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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Aug 17;8(5):1228–1239. doi: 10.1161/CIRCEP.115.003155

Figure 5.

Figure 5

DIV-LFS (S1618C) ionic currents and fluorescence. Na+ currents and fluorescence from DIV-LFS. Mean±95CI is reported for groups of 3 to 20 cells. A) Top: Ionic currents (above) and fluorescence (below) as in Figure 2. Only traces from -150, -90, -30, and +30 mV are shown for clarity. G-V (black circles) and SSI (black squares), and the corresponding fluorescence signals (purple circles and squares, respectively). Curves were constructed as in Figure 2. Boltzmann-fit parameters in Table 1. Dotted lines represent WT G-V and SSI curves for comparison. B) Top: Tail currents and fluorescence measured during step back to -120 mV from steps to +50 mV for 2 (black) or 200 ms (green) pulses. Bottom: t10-90%,C values calculated from deactivation time constants of the fluorescence signal from exponential fits following the step back to -120 mV, from depolarizing steps to 0 or +50 mV for 1 to 200 ms durations.