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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Nat Immunol. 2015 Sep 28;16(11):1142–1152. doi: 10.1038/ni.3268

Figure 8. Rac1G12V knock-in fully rescues the Mst1/2-deficient phenotype.

Figure 8

(a) Mst1fl/flMst2fl/fl (WT), Mst1fl/flMst2fl/flLyz2-Cre (cDKO) and cDKO-Rac1G12V BMDMs were infected with GFP-E. coli for the indicated times and the GFP-E. coli was quantified by fluorescence microscopy. Data were assessed with Student's t test and are represented as mean ± s.d. n=5. * p<0.05, ** p<0.01 in a comparison of cDKO and cDKO-Rac1G12V groups.

(b) Mortality of WT (n=11), Rac1G12V (n=10), cDKO (n=10) or cDKO-Rac1G12V (n=11) mice subjected to sublethal CLP. The Mantel–Cox test, p=0.046 compared between cDKO and cDKO-Rac1G12V groups.

Data are from one experiment representative of three independent experiments with similar results (a, b).