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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Curr Opin Plant Biol. 2015 Jun 3;27:22–28. doi: 10.1016/j.pbi.2015.05.007

Figure 2. Molecular glue mechanism of auxin perception and Aux/IAA recognition by SCFTIR1/AFB.

Figure 2

The x-ray crystal structure of the SCFTIR1/AFB•auxin•IAA7 peptide complex (PDB: 2P1Q; [22]) revels the presence of an auxin binding pocket that mediates Aux/IAA protein interaction. The overall structure of the complex formed by AtTIR1 (gray), AtASK1 (light purple), IAA (green), and a peptide corresponding to the AtIAA7 degron (blue) is shown. The inset depicts the TIR1 auxin-binding pocket, in which auxin acts as a molecular glue to allow interaction with Aux/IAA protein degron motifs.