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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Nat Chem Biol. 2015 Sep 14;11(11):834–836. doi: 10.1038/nchembio.1910

Figure 1. Chemical screening using isolated mitochondria identifies suppressors of site IIIQo superoxide production.

Figure 1

(a – f) Structures of S3QELs 1-3 and dose-response curves against two ΔΨm and six H2O2 endpoint screening assays (n = 1). Mean IC50 values against site IIIQo superoxide production were 0.75, 1.7, and 0.35 μM for S3QELs 1-3, respectively. (g – i) Effects of S3QELs 1-3 on the steady state rate of H2O2 production measured using the Amplex UltraRed assay (normalized mean ± SE, n = 3 biological replicates). **p < 0.01 versus DMSO in each condition; one-way ANOVA with Dunnett’s posttest. Glu, glutamate; Mal, malate; Suc, succinate; Rot, rotenone; IF/DH, site IF plus NADH-linked matrix dehydrogenases.