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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Cell Rep. 2015 Oct 8;13(3):479–488. doi: 10.1016/j.celrep.2015.09.022

Figure 4. SIRT6 cancer-associated point mutations fail to repress anchorage independent growth.

Figure 4

(A) Quantification of colonies grown in soft agar of SIRT6 KO MEFs expressing each mutant. Data are shown as mean ± s.e.m. between triplicates in four independent experiments. (B) Representative pictomicrographs of colonies. (C) Gross images of subcutaneous tumors grown in SCID mice of SIRT6 KO cells re-expressing the indicated SIRT6 constructs (n=5) (D) Quantification of tumor weight from (C). *= p ≤ 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001.