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. 2015 Oct 21;15:756. doi: 10.1186/s12885-015-1760-5

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© Tao et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The GATA4 promoter is methylated in AML cell lines. a Four CpG island regions can be identified in the promoter of GATA4. b MSP analysis of the methylation status of GATA4 in leukemia cell lines showing hypermethylation in 5/11 cell lines. M and U represent MSP results using primer sets for methylated and unmethylated GATA4 genes, respectively. c Western blot analysis the expression of GATA4 in 9 NBM samples and 9 leukemia cell lines. d The GATA4 transcript level is upregulated in cells treated with 5-Aza compared to DMSO: 19.2-fold in HL-60 cells (5-Aza: 19.23 vs. DMSO: 1.00; P = 0.003); 12.5-fold in MV4-11 cells (5-Aza: 29.23 vs. DMSO: 2.33; P = 0.05)