Table 2.
Association of GATA4 promoter methylation with clinico-pathological characteristics in 105 pediatric AML samples
| Clinical variables | No. of patients | GATA4 methylation (n) | P | |
|---|---|---|---|---|
| Negative | Positive | |||
| Sex | ||||
| Male | 42 | 21 | 21 | 0.297 |
| Female | 63 | 25 | 38 | |
| Age (years) | ||||
| < 6 | 60 | 28 | 32 | 0.496 |
| ≥ 6 | 45 | 18 | 27 | |
| Leukocyte (/μl) | ||||
| > 10,000 | 61 | 32 | 29 | 0.035 |
| ≤ 10,000 | 44 | 14 | 30 | |
| FAB | ||||
| M1–M6 | 93 | 38 | 55 | 0.090 |
| M7 | 12 | 8 | 4 | |
| Cytogenetics | ||||
| Favorable | 50 | 16 | 34 | 0.062 |
| Intermediate | 27 | 14 | 13 | |
| Unfavorable | 28 | 16 | 12 | |
| MRD | ||||
| < 0.25 % | 49 | 16 | 33 | 0.031 |
| ≥ 0.25 % | 56 | 30 | 26 | |