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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Mod Pathol. 2015 Jul 31;28(10):1390–1399. doi: 10.1038/modpathol.2015.86

Table 3. Concomitant mutations of KRAS, NBAS, BRAF, and PIK3CA genes.

Genes Tumors PIK3CA exon 9 PIK3CA exon 20
KRAS+PIK3CA 24 17 4
BRAF+PIK3CA 4 1 2
NRAS+PIK3CA 2 0 1
PIK3CA+PIK3CA 2 1 0
KRAS+KRAS la
KRAS+BRAF 3b
KRAS+NBAS 3c
a

p.Gl2A and p.Gl3D.

b

KRAS p.Gl5S (c.43G4 A) and BRAF p.V600E (c.1799T4 A); KRAS p.A59E (c.l76C4 A) and BRAF p.D594G (c.1781A4 G); and KRAS p.G12V (c.35G4 T) and BRAF p.Y472C (c.1415A4 G).

C

KRAS p.Gl2D (c.354 G4 A) and NRAS p.Q61K (c.181C4 A); KRAS p.A146T (c.436G4 A) and NRAS p.Q61R (C.182A4 G); and KRAS p.G12V(c.35G4 T) and NRAS p.G13C (c.37G4 T).