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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Mol Genet Metab. 2015 Jul 20;116(0):24–28. doi: 10.1016/j.ymgme.2015.07.004

Figure 1. Cellular and molecular mechanisms of MDS.

Figure 1

Immune cells, osteoblasts, and mesenchymal stromal cells (MSCs) express signaling molecules that influence MDS HSC signaling and function. Hypoxia also has the capacity to directly and indirectly influence the behavior of MDS HSCs.