Skip to main content
. 2015 May 21;6(8):4561–4569. doi: 10.1039/c5sc01507c

Table 4. RCM on peptides bearing i, i + 4 and i, i + 7 olefin crosslinks.

Inline graphic
Catalyst Conversion a (%)
Selectivity a (E : Z)
26 27 28 29 30 31 26 27 28 29 30 31
m, n = 1 m, n = 1 m, n = 1 m, n = 4 m, n = 4 m, n = 4 m, n = 1 m, n = 1 m, n = 1 m, n = 4 m, n = 4 m, n = 4
1 94 90 93 88 96 92 66 : 23 64 : 36 70 : 30 58 : 42 62 : 38 65 : 35
2 97 90 85 94 95 90 80 : 20 75 : 25 83 : 17 80 : 20 75 : 25 79 : 21
3 84 81 88 80 84 85 80 : 20 75 : 25 74 : 26 78 : 22 78 : 22 80 : 20
4 88 80 92 85 88 85 72 : 28 74 : 26 72 : 28 71 : 29 81 : 19 81 : 19
5 76 70 70 60 84 80 66 : 33 70 : 30 74 : 26 n.d. 71 : 29 74 : 26
6 83 75 80 70 80 75 20 : 80 22 : 78 18 : 82 20 : 80 21 : 79 17 : 83
7 81 75 70 55 75 70 17 : 83 19 : 81 23 : 77 n.d. 18 : 82 20 : 80

aDetermined by analytical HPLC-MS.