Table 4. RCM on peptides bearing i, i + 4 and i, i + 7 olefin crosslinks.
| ||||||||||||
Catalyst | Conversion
a
(%) |
Selectivity
a
(E : Z) |
||||||||||
26 | 27 | 28 | 29 | 30 | 31 | 26 | 27 | 28 | 29 | 30 | 31 | |
m, n = 1 | m, n = 1 | m, n = 1 | m, n = 4 | m, n = 4 | m, n = 4 | m, n = 1 | m, n = 1 | m, n = 1 | m, n = 4 | m, n = 4 | m, n = 4 | |
1 | 94 | 90 | 93 | 88 | 96 | 92 | 66 : 23 | 64 : 36 | 70 : 30 | 58 : 42 | 62 : 38 | 65 : 35 |
2 | 97 | 90 | 85 | 94 | 95 | 90 | 80 : 20 | 75 : 25 | 83 : 17 | 80 : 20 | 75 : 25 | 79 : 21 |
3 | 84 | 81 | 88 | 80 | 84 | 85 | 80 : 20 | 75 : 25 | 74 : 26 | 78 : 22 | 78 : 22 | 80 : 20 |
4 | 88 | 80 | 92 | 85 | 88 | 85 | 72 : 28 | 74 : 26 | 72 : 28 | 71 : 29 | 81 : 19 | 81 : 19 |
5 | 76 | 70 | 70 | 60 | 84 | 80 | 66 : 33 | 70 : 30 | 74 : 26 | n.d. | 71 : 29 | 74 : 26 |
6 | 83 | 75 | 80 | 70 | 80 | 75 | 20 : 80 | 22 : 78 | 18 : 82 | 20 : 80 | 21 : 79 | 17 : 83 |
7 | 81 | 75 | 70 | 55 | 75 | 70 | 17 : 83 | 19 : 81 | 23 : 77 | n.d. | 18 : 82 | 20 : 80 |
aDetermined by analytical HPLC-MS.