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. 2015 May 21;6(8):4561–4569. doi: 10.1039/c5sc01507c

Table 5. Z-Selective ethenolysis on stapled peptides bearing i, i + 4 and i, i + 7 crosslinks.

Inline graphic
Entry Compound Initial E : Z a Final E : Z a Conversion a %
1 26 72 : 28 95 : 5 86%
2 27 83 : 17 93 : 7 65%
3 28 71 : 29 96 : 4 91%
4 29 79 : 21 94 : 6 78%
5 30 64 : 36 98 : 2 83%
6 31 81 : 19 98 : 2 93%

aDetermined by analytical HPLC/MS of cleaved peptide.