Table 2.
Zidovudine (ZDV)-resistant mutations by time, plasma HIV RNA and CD4 T-cell counts. Resistance detected by pyrosequencing of plasma (HIV-1 RNA) at delivery and after 30 days of postpartum tail, and PBMC (HIV-1 DNA) at 24 weeks postpartum.
| Subject | ZDV- resistance mutations detected |
ZDV duration at delivery (weeks) |
ZDV-resistance mutation representation in HIV population by duration of ZDV |
Plasma HIV RNA (copies/mL) |
CD4 T- cells at study entry |
|||
|---|---|---|---|---|---|---|---|---|
| Delivery | After 30 day ZDV+ddI tail† |
24 weeks postpartum |
Study entry |
Delivery | ||||
| 1 | K70R | 10.0 | 2% | ^ | 0% | 28,200 | 24,000 | 431 |
| 2 | M41L | 9.0 | 1.1% | 0% | 0% | 51,300 | 55,000 | 252 |
| D67N | 11% | 13.8% | 0% | |||||
| K70R | 24.5% | 87.0% | 1.6% | |||||
| 3 | D67N | 7.5 | 3.2% | ^ | 0% | 39,800 | 46,800 | 317 |
| 4 | K70R | 14.4 | 5% | ^ | 0% | 6,900 | 6,200 | 586 |
| 5 | K70R | 31.0 | 2.5% | ^ | 0% | 5,200 | 3,500 | 484 |
| 6 | D67N | 12.0 | 1.5% | 2.0% | 0% | 14,366 | 15,586 | 365 |
| K70R | 0% | 2.0% | 0% | |||||
| 7 | K70R | 13.0 | 2% | ^ | 0% | 12,621 | 11,208 | 291 |
| 8 | D67N | 11.9 | 0% | 1.6% | 0% | 5,800 | 7100 | 368 |
^
not tested
†
subjects in Arm B tested at completion of a 30-day ZDV+ddI tail