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Notch1 inhibition abrogates cleaved Notch1 activity and increases apoptosis. (a) Treatment with the Notch1 antibody reduces cleaved Notch1 in sensitive and resistant tumors at the end of study. (b) Notch1 blockade increases apoptosis as shown by an increase in cleaved caspase 3 in the CRC001- and CRC036-sensitive CRC explants. (c) A representative picture showing elevations in cleaved caspase 3 (brown staining) in control and Notch1-treated after 3 days of treatment in CRC040.
