Skip to main content
. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Inorg Chem. 2015 Sep 23;54(19):9626–9636. doi: 10.1021/acs.inorgchem.5b01722

Figure 1.

Figure 1

Chemical structures of complexes studied. [Rh(chrysi)(phen)(DPE-Pt(NH3)2Cl]3+ (left) is a bifunctional complex comprised of a trisheteroleptic rhodium metalloinsertor, which recognizes DNA mismatches, tethered to a cis-platinum (II) anticancer agent, which forms covalent adducts with DNA. [Rh(chrysi)(phen)(DPE)]2+ (center) is the rhodium metalloinsertor parent complex, which contains an unusual Rh—O axial coordination that contributes to its enhanced efficacy. Cis-dichlorodiammineplatinum (II) (right) is the FDA-approved chemotherapeutic known as cisplatin.