Table 3.

Top 15 KEGG Pathways Enriched in Genes Affected by CNVs in Qataris^a

Kegg pathway	Number of genes	Fold-enrichment	p value
Notch signaling pathway	16	2.7	4.4 × 10−4
Starch and sucrose metabolism	14	2.6	1.5 × 10−3
Focal adhesion	39	1.5	6.4 × 10−3
mTOR signaling pathway	14	2.1	1.1 × 10−2
Purine metabolism	30	1.5	1.6 × 10−2
Antigen processing and presentation	19	1.8	1.4 × 10−2
Axon guidance	25	1.5	3.2 × 10−2
Type II diabetes mellitus	12	2	3.0 × 10−2
Drug metabolism	14	1.8	4.4 × 10−2
Extracellular matrix - receptor interaction	17	1.6	6.0 × 10−2
Type I diabetes mellitus	10	1.9	7.6 × 10−2
Non-small cell lung cancer	12	1.8	7.2 × 10−2
Insulin signaling pathway	24	1.4	8.2 × 10−2
Metabolism of xenobiotics by cytochrome P450	13	1.7	7.0 × 10−2
Maturity onset diabetes of the young	7	2.2	8.7 × 10−2

^aAll genes affected by CNVs in Qataris were analyzed by DAVID bioinformatics resources for KEGG pathways. Number of genes in each enriched KEGG Pathway, along with the fold-enrichment within each pathway and a p value for the significance of enrichment