Table 6.

Top 10 Cytobands in Which Qatari Genetic Subpopulations’ CNVRs were Observed at a Significantly Higher Frequency than in 1000 Genomes Phase I CNV Data^a

Qatari genetic subpopulation	Cytoband	1000Genomes phase I count	Q1, Q2 or Q3 count	p value	Diseases associated with cytoband
Q1	1q21.1	10	55	1.60 × 10−16	Schizophrenia; congenital heart disease
	9q21.11	5	42	1.06 × 10−14	-
	5q13.2	6	35	3.43 × 10−11	Neurologic disorders; alcohol dependence
	9p11.2	17	49	8.97 × 10−11	-
	16p11.2	23	50	7.10 × 10−9	Autism; schizophrenia; obesity
	10q11.22	7	29	2.45 × 10−8	-
	9p12	14	38	2.66 × 10−8	-
	8p11.1	2	20	7.14 × 10−8	-
	9p13.1	8	29	7.55 × 10−8	-
	7q11.1	3	20	3.66 × 10−7	-
Q2	1q21.1	10	59	9.67 × 10−22	Schizophrenia; congenital heart disease
	5q13.2	6	36	8.21 × 10−14	Neurologic disorders; alcohol dependence
	9q21.11	5	33	4.22 × 10−13	-
	16p11.2	23	51	8.07 × 10−12	Autism; schizophrenia; obesity
	9p11.2	17	44	1.17 × 10−11	-
	7q11.1	3	25	8.91 × 10−11	-
	8p11.1	2	20	3.77 × 10−9	-
	7q11.21	35	53	5.43 × 10−9	-
	10q11.22	7	26	8.97 × 10−9	-
	9p12	14	30	1.76 × 10−7	-
Q3	1q21.1	10	60	2.04 × 10−20	Schizophrenia; congenital heart disease
	9q21.11	5	37	7.23 × 10−14	-
	9p11.2	17	48	6.27 × 10−12	-
	16p11.2	23	54	1.26 × 10−11	Autism; schizophrenia; obesity
	5q13.2	6	33	1.83 × 10−11	Neurologic disorders; alcohol dependence
	10q11.22	7	29	3.10 × 10−9	-
	7q11.1	3	21	3.00 × 10−8	-
	22q11.1	7	25	1.20 × 10−7	-
	8p11.1	2	18	1.24 × 10−7	-
	1p36.33	12	30	2.87 × 10−7	Disorders of sexual development; obesity

^aAll CNVRs detected in Q1, Q2 and Q3 Qataris as well as all CNVRs in the Database of Genomic Variantsfrom the 1000 Genomes Project Phase I [25] data were annotated for which chromosome and cytoband they affected. Fisher’s exact test was used to evaluate enrichment or depletion of CNVRs from a specific cytoband, corrected p value for significance (<6.7 × 10⁻⁶)