Table 1.

Demographic Characteristics, Clinical Symptoms, and Fecal Testing Results of the 5 Patients Described in This Study

Characteristic	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
Age at presentation in  months	22.5	4.6	2.9	2.3	6.2
Symptoms
Diarrhea
Duration; maximum    episodes in 24 h	None	5 d; 4 episodes	3 d; 18 episodes	None	1 d; 5 episodes
Vomiting
Duration; maximum    episodes in 24 h	1 d; 11 episodes	None	None	4 d; 3 episodes	1 d; 12 episodes
Fever
Duration; maximum	1 d; 38.8°C (rectal)	5 d; 38.6°C (rectal)	1 d; 38.3°C (rectal)	2 d; 39.4°C (axillary)	1 d; 38.6°C (rectal)
Intravenous rehydration	Yes	None	None	None	Yes
Hospitalization for AGE   episode	Yes; 23-hour stay	Yes; 23-hour stay	None	None	Yes; 23-hour stay
Race/ethnicity	White, non-Hispanic	White, Hispanic	White, Hispanic	Middle Eastern, non- Hispanic	White, non-Hispanic
Birth history
Gestation, birth weight	Term, 7 lb 3 oz	Term, 7 lb 13 oz	Term, 9 lb 8 oz	Term, 7 lb 12 oz	Term, 6 lb 9 oz
History of breastfeeding
Duration	Yes; 7–12 mo	Yes; <1 mo	Yes; 1–3 mo	Yes; <1 mo	Yes; 1–3 mo
Other children in the home	1 sibling aged <6 mo	2 siblings, both aged  ≥5 y	2 siblings, both aged  ≥5 y	None	1 sibling, aged 2.5 y
Daycare attendance	None	None	None	None	None
Rotavirus vaccination history
Patient	No doses RV1 or RV5	1st dose RV5 11 d prior  to illness onset	1st dose RV5 2 d prior  to illness onset	1st dose RV5 1 d prior  to illness onset	No doses RV5 or RV1
Other children aged <5 y  in the home	2nd dose RV5 7 d  before patient’s illness onset	NAa	NAa	NAa	No doses RV5 or RV1
Timing of fecal specimen  collection	2 d after illness onset	9 d after illness onset	5 d after illness onset	3 d after illness onset	8 d after illness onset
Rotavirus strain detected	1 RV5 vaccine-  reassortant strain	1 RV5 double vaccine-  reassortant strain	1 RV5 vaccine strain	1 RV5 vaccine strain &  3 RV5 vaccine-  reassortant strains	RV1 vaccine strain
AGE coinfectionsb	Unidentified particles  30–40 nm in  diameter	Adenovirus group F	Unidentified particles  30 nm in diameter	Norovirus genogroup II	Unidentified particles  40–45 nm in  diameter

Abbreviations: AGE, acute gastroenteritis; NA, not applicable; RV1, Rotarix vaccine; RV5, RotaTeq vaccine.

^aOther children in the home were ≥5 years at the time of the patient’s illness, and, therefore, were born before rotavirus vaccine was licensed in the United States.

^bSpecimens were tested for norovirus genogroups I and II, astroviruses, sapoviruses, enteroviruses, parechoviruses [11–14], adenovirus, Salmonella, Shigella, Campylobacter, diarrheagenic Escherichia coli, and Vibrios.