Table 2.
Patient and tumor baseline characteristics for patients receiving chemotherapy alone or chemotherapy and targeted therapies
| Characteristics | Chemotherapy only | P-value | Chemotherapy and antibody treatment | P-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI (kg/m2) | BMI (kg/m2) | |||||||||||
| Under-weight (n = 34) | Normal (n = 314) | Over-weight (n = 298) | Obese I (n = 116) | Obese II (n = 52) | Under-weight (n = 8) | Normal (n = 104) | Over-weight (n = 164) | Obese I (n = 59) | Obese II (n = 25) | |||
| Age (mean) | 66.0 | 65.9 | 65.8 | 64.4 | 63.5 | 0.36 | 62.5 | 60.9 | 61.9 | 59.9 | 63.1 | 0.57 |
| Sex (%) | ||||||||||||
| Female | 58.81 | 36.1 | 33.21 | 44.0 | 47.2 | 0.01 | 62.5 | 42.7 | 32.3 | 31.0 | 44.0 | 0.16 |
| Male | 41.21 | 63.9 | 66.81 | 56.0 | 52.8 | 37.5 | 57.3 | 67.7 | 69.0 | 56.0 | ||
| Synchronous disease (%) | 61.8 | 77.71 | 65.9 | 56.0 | 58.5 | 0.001 | 62.5 | 77.91 | 61.6 | 69.5 | 56.0 | 0.05 |
| No. of met sites (%) | ||||||||||||
| 1 | 73.5 | 73.2 | 75.5 | 73.3 | 71.7 | 0.96 | 87.5 | 76.0 | 71.3 | 74.6 | 72.0 | 0.81 |
| >1 | 26.5 | 26.8 | 24.5 | 26.7 | 28.3 | 12.5 | 24.0 | 28.7 | 25.4 | 28.0 | ||
| No of lines of chemo (%) | ||||||||||||
| 1 | 55.9 | 51.3 | 45.1 | 54.3 | 66.0 | 0.38 | 25.0 | 27.9 | 30.5 | 27.1 | 24.0 | 0.74 |
| 2 | 32.4 | 31.2 | 35.4 | 30.2 | 18.9 | 25.0 | 26.9 | 22.6 | 33.9 | 32.0 | ||
| 3 | 8.8 | 12.4 | 14.1 | 11.2 | 7.5 | 50.0 | 27.9 | 26.2 | 25.4 | 28.0 | ||
| 4 | 2.9 | 3.2 | 4.0 | 4.3 | 7.5 | 15.4 | 12.8 | 10.2 | 12.0 | |||
| 5+ | – | 1.9 | 1.3 | – | – | – | 1.9 | 7.9 | 3.4 | 4.0 | ||
| No. of lines of antibody (%) | ||||||||||||
| 0 | _ | _ | _ | _ | _ | _ | _ | _ | _ | – | 0.56 | |
| 1 | – | – | – | – | – | 87.5 | 70.2 | 78.7 | 76.3 | 80.0 | ||
| 2 | _ | _ | _ | _ | _ | 23.1 | 15.2 | 18.6 | 20.0 | |||
| 3 | – | – | – | – | – | 12.5 | 6.7 | 6.1 | 5.1 | – | ||
| %pt KRAS tested | 5.9 | 22.9 | 20.8 | 20.7 | 11.3 | 0.08 | 75.0 | 45.2 | 49.4 | 49.2 | 60.0 | 0.41 |
| Type of KRAS (%) | ||||||||||||
| KRAS wild type | 50.0 | 55.6 | 41.9 | 58.3 | 50.0 | 0.53 | 83.3 | 72.3 | 74.1 | 62.1 | 80.0 | 0.65 |
| KRAS mutant | 50.0 | 44.4 | 58.1 | 41.7 | 50.0 | 16.7 | 27.7 | 25.9 | 37.9 | 20.0 | ||
P-values are based on ANOVA for continuous data and Chi-square test for categories.
1
Denotes a subset of BMI categories whose column proportions differ significantly from the other columns at the 0.5 level.