Table 1.
EBV-T-LPDs patients and their EBV-infected cells in the peripheral blood subjected to the assay
| Case | Gender | Age | Infected cell | Clinical findings | Clonality of the infected cells | EBV DNA load of each fraction of PBMCs (copies/μgDNA) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | CD4 | CD8 | CD56 | CD14 | CD19 | Others | ||||||
| CD4-1 | F | 25 | CD4 | HMB | Mono | 7.0 × 104 | 2.2 × 105 | ND | ND | ND | ND | ND |
| CD4-2 | M | 28 | CD4 | HLH | Mono | 2.3 × 104 | 9.2 × 104 | ND | ND | ND | ND | 2.3 × 103 |
| CD4-3 | M | 41 | CD4 | sCAEBV | Mono | 1.7 × 103 | 1.7 × 104 | ND | ND | ND | 1.0 × 104 | ND |
| CD8-1 | F | 21 | CD8 | sCAEBV | Mono | 1.8 × 103 | ND | 6.0 × 102 | ND | ND | ND | ND |
| CD8-2 | F | 28 | CD8 | HMB, HLH | Mono | 4.9 × 104 | 1.5 × 105 | ND | ND | ND | ND | ND |
| CD8-3 | M | 28 | CD8 | sCAEBV | Mono | 1.3 × 105 | 1.2 × 102 | 2.0 × 106 | 1.7 × 103 | ND | 2.0 × 104 | ND |
| CD8-4 | F | 64 | CD8 | sCAEBV | Mono | 2.6 × 105 | ND | 1.2 × 106 | ND | ND | 4.6 × 105 | ND |
EBV-T-LPDs, Epstein–Barr virus-positive T-cell lymphoproliferative diseases; PBMCs, peripheral blood mononuclear cells; M, male; F, female; HMB, hypersensitivity to mosquito bites; HLH, hemophagocytic lymphohistiocytosis; sCAEBV, systemic chronic active Epstein–Barr virus infection; Mono, monoclonal; ND, not detected.