Table 2.
HR from cox regression models of OPC survival
| Variable | Overall survivalHR (95% CI) | OPC-specific survivalHR (95% CI) |
|---|---|---|
| Age at diagnosis | 1.32 (1.30–1.35) | 1.39 (1.35–1.43) |
| Gender | ||
| Female | 1.00 | 1.00 |
| Male | 1.10 (1.06–1.14) | 1.03 (0.97–1.09) |
| Race-ethnicity | ||
| White, non-Hispanic | 1.00 | 1.00 |
| Black, non-Hispanic | 1.25 (1.17–1.32) | 1.23 (1.12–1.36) |
| Hispanic | 0.95 (0.89–1.02) | 0.94 (0.84–1.06) |
| Marital status | ||
| Married | 1.00 | 1.00 |
| Single | 1.25 (1.21–1.30) | 1.29 (1.22–1.37) |
| Unknown | 1.10 (1.01–1.21) | 1.12 (0.96–1.31) |
| Insurance | ||
| Private | 1.00 | 1.00 |
| Uninsured | 1.62 (1.51–1.75) | 1.83 (1.63–2.05) |
| Medicaid | 1.63 (1.52–1.75) | 1.86 (1.67–2.07) |
| Medicare | 1.27 (1.20–1.34) | 1.41 (1.28–1.54) |
| Medicare with supplement | 1.11 (1.05–1.17) | 1.12 (1.02–1.22) |
| Other | 1.11 (1.04–1.17) | 1.12 (1.02–1.23) |
| Unknown | 1.28 (1.18–1.39) | 1.50 (1.31–1.72) |
| Year of diagnosis | ||
| 1996–2000 | 1.00 | 1.00 |
| 2001–2005 | 1.10 (1.06–1.14) | 0.77 (0.72–0.83) |
| 2006–2010 | 1.09 (1.04–1.14) | 0.58 (0.54–0.62) |
| Anatomic site | ||
| Oral SCC | 1.00 | 1.00 |
| Pharyngeal SCC | 0.87 (0.83–0.90) | 0.72 (0.68–0.77) |
| Other head and neck sites | 0.86 (0.82–0.91) | 0.75 (0.68–0.81) |
| Stage of diagnosis | ||
| Local | 1.00 | 1.00 |
| Regional | 1.45 (1.38–1.51) | 1.82 (1.68–1.97) |
| Distant | 2.40 (2.26–2.55) | 3.22 (2.92–3.55) |
| Unstaged | 1.29 (1.22–1.37) | 1.62 (1.47–1.79) |
| Treatment | ||
| Surgery only | 1.00 | 1.00 |
| Surgery + radiation and/or chemo | 1.04 (0.99–1.09) | 1.17 (1.07–1.28) |
| Radiation and/or chemo only | 1.40 (1.33–1.47) | 1.74 (1.60–1.89) |
| Unknown | 1.98 (1.87–2.10) | 2.50 (2.26–2.76) |
| Socioeconomic status | ||
| High | 1.00 | 1.00 |
| Middle | 1.12 (1.08–1.17) | 1.18 (1.11–1.25) |
| Low | 1.26 (1.20–1.33) | 1.37 (1.26–1.49) |
| Regional smoking | ||
| ≤15.0% | 1.00 | 1.00 |
| 15.1–20.0% | 1.17 (1.10–1.25) | 1.39 (1.24–1.56) |
| 20.1–25.0% | 1.21 (1.14–1.29) | 1.49 (1.33–1.66) |
| ≥25.1% | 1.25 (1.15–1.35) | 1.56 (1.36–1.79) |
| Individual smoking | ||
| Nonsmokers | 1.00 | 1.00 |
| Smokers (former or current) | 1.36 (1.30–1.42) | 1.48 (1.37–1.59) |
All chosen predictor variables were included in the final model. HR, hazard ratios; OPC, oral and pharyngeal cancer; SCC, squamous cell carcinoma.