Table 1.

Model parameter estimates for the dynamics of IL-1β and IL-6 proteins

Parameter (Units)	Definition	Estimate	CV %
kin2P (pmol h−1 nmol_mRNA−1)	Synthesis rate constant for IL-1β protein	3.94 × 10−5	7.45
S2	Proportionality constant of disease-stimulated IL-1β mRNA and protein	0.454	0.674
IL-1βP0 (pmol mg_protein−1)	IL-1β protein baseline	0.00129	FIXED
kin3P (pmol h−1 nmol_mRNA−1)	Synthesis rate constant for IL-6 protein	1.63 × 10−4	38.2
S3	Proportionality constant of disease-stimulated IL-6 mRNA and protein	0.00332	5.33
IL-6P0 (pmol mg_protein−1)	IL-6 protein baseline	0.00116	FIXED

CV %, coefficient of variation.