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Using phospholipid and plasma protein binding to visualize molecules whose distribution is less governed by nonspecific binding. Three molecules containing quaternary ammonium groups are well distributed into muscular tissue (heart and skeletal shown here) but not other tissues (e.g., lung) by a mechanism less influenced by nonspecific binding. Reducing lipophilicity (e.g., by excluding molecules where cLogP > 3) decreases the influence of nonspecific binding on drug distribution.
