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Diagrammatic representation of factors governing distribution of acidic drugs (upper panel) and basic drugs (lower panel). Strongly acidic moieties (acidic pKa < 7) and strongly basic moieites (basic pKa > 7) are ionized at physiological pHs. Whereas acidic moieties bind to serum albumin in plasma, basic moieties bind to phoshoplipids in cells or can be sequestered in acidic organelles.
