Table 1.

Glossary of terms

Tissue: blood area under curve (AUC) ratio of radioactivity (T:B)	Calculated from quantitative whole body autoradiography studies (QWBA) studies by dividing the AUC of drug radioactivity concentration in tissues by that in blood
Tissue: plasma ratio (T:P)	Calculated from rat metabolism studies by dividing tissue concentrations of either parent drug or radioactivity by the corresponding plasma concentration at the same sample time
Base pKa	Basic pKa predicted using proprietary software
Acid pKa	Acidic pKa predicted using proprietary software
Predicted tissue/plasma partition coefficient (Kp)	Predicted using Lukacova option in Gastroplus software version 8.6
Chromatographic hydrophobicity index – immobilized artificial membrane (CHI-IAM)	A measure of phospholipid binding derived from high-performance liquid chromatography (HPLC) retention using an immobilized artificial membrane stationary phase
cLogP	A measure of lipophilicity. cLogP is the logarithm of the partition coefficient between n-octanol and water log(coctanol/cwater) predicted from structure