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. 2015 Sep 1;3(5):e00178. doi: 10.1002/prp2.178

Figure 3.

Figure 3

In vivo validation of RS4;11-LMC seeding following systemic inoculation. (A) Dose titration of RS4;11-LMC cells inoculated via the tail vein at 2 × 106, 1 × 106 and 5 × 105 cells/mouse. N = 10 mice per titration, data presented as mean BLI ± SEM. Graphs for the individual mice inoculated at 2 × 106 cells are shown. (B) Representative images from an individual mouse (#905) inoculated with 2 × 106 cells in A. (C) H&E and luciferase IHC staining in the leg of the RS4;11-LMC systemic engraftment model. (D) H&E and luciferase IHC staining in the lung, liver, and spleen of RS4;11-LMC systemic engraftment model. (E) Comparison of monitored growth rates of RS4;11-LMC using whole-body ROI or legs only ROI as the growth parameter.